hrp0089fc5.6 | Thyroid | ESPE2018

Alterations in DNA Methylation Status of Gene Promoters in Children and Adolescents with Autoimmune Thyroid Disease

Kyrgios Ioannis , Fragkou Aikaterini , Efraimidou Smaragda , Tzimagiorgis Georgios , Emporiadou-Petikopoulou Maria , Galli-Tsinopoulou Assimina

Background: Hashimoto Thyroiditis (HT) and Graves Disease (GD) are conditions known to be caused by abnormal immune response against self-tissues. The biological processes at molecular lever are still poorly understood. A few epigenetic studies have been published so far.Objective: To investigate whether there are differences in DNA methylation within the HLADRB1, CD40L, FOXP3, CTLA4, FCRL3, IL2RA and PTPN22 promoters between young patients with autoimmu...